The Ohio River is one of the most notable and known locations in Knox Country. It is the largest body of water in the game, and separates the playable map from the unplayable side.
The Ohio River stretches across the top of the entire map. It borders cities such as Riverside, Brandenburg, West Point, and Louisville. It supplies the sole survivor an infinite quantity of tainted water.
There are currently only two bridges crossing the Ohio River. One in Louisville near the Body Chisel gym which has been blocked off, and the other in an unfinished city presumed to be Brandenburg, which is also blocked off. The river can be crossed by building wooden floors over it, or with debug mode, by either teleporting or enabling 'no clip'. However, there is currently nothing but plains and trees on the other side.
On July 16th (day 7) the bridges crossing the Ohio River were demolished by the military at 1200 EDT, killing hundreds of civilians, and trapping many more south of the Ohio River. This is believed to be an attempt at slowing the Knox Infection and keeping it out of Ohio. However, cases were quickly reported north of the river, which were believed to be caused by the 'aerial strain'.
A couple of calls can be listened to on the radio mentioning the Louisville bridge being blocked and demolished.
Prior to the Knox Event, Cal Fairweather, the then governor of Kentucky, often received complaints about the Ohio River being one of the most polluted rivers in America. A discussion about this can be found on the VHS tape Fairweather-Mahoney 2/11/93.
- The Ohio River is a real location that runs through the states of Illinois, Indiana, Kentucky, Ohio, Pennsylvania, and West Virginia, which flows into the Mississippi River.